Ovarian odorant-like biomolecules in promoting chemotaxis behavior of spermatozoa olfactory receptors during migration, maturation, and fertilization

Abstract Background Studies have shown that olfactory receptor genes are the largest in human genome, which significantly expressed and non-olfactory tissues such as reproductive systems where they perform many important biological functions. Main body There is growing evidence bioactive metabolites from ovary, follicular fluid, other parts of female tract signal sperm through a series transduction cascades regulate migration, maturation, fertilization processes. Several studies highlighted role G-protein-coupled receptors these cellular Thus, we aimed to summarize existing describing physiological most prominent exogenous endogenous biomolecules found organ enhancing chemotaxis behavior spermatozoa during also elucidate pathological implications its dysfunctions clinical significance fertility. Short conclusion In future, drugs molecules can be designed activate on facilitate fertility among infertile couples use contraceptives.